Dr Rebecca San Gil
FightMND Research Fellow
Queensland Brain Institute
| Featured projects | Duration |
|---|---|
|
Genome-wide CRISPR screening for modifiers of diverse cellular phenotypes Genome Innovation Hub Collaborative Project (UQ infrastructure) |
2019 |
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Optimised bioinformatics and validation pipeline for genome-wide CRISPR screening data Genome Innovation Hub Collaborative Project (UQ infrastructure) |
2021 |
Publications
Journal Articles
Cheng, Flora, Chapman, Tyler, Venturato, Juliana, Davidson, Jennilee M., Polido, Stella A., Rosa‐Fernandes, Livia, San Gil, Rebecca, Suddull, Hannah J., Zhang, Selina, Macaslam, Chiara Y., Szwaja, Paulina, Chung, Roger, Walker, Adam K., Rayner, Stephanie L., Morsch, Marco and Lee, Albert (2025). Proteomics Analysis of the TDP ‐43 Interactome in Cellular Models of ALS Pathogenesis. Journal of Neurochemistry, 169 (5) e70079. doi: 10.1111/jnc.70079
San Gil, Rebecca and Walker, Adam K. (2025). Unlocking Disease‐Modifying Treatments for TDP‐43‐Mediated Neurodegeneration. BioEssays, 47 (4) e202400257. doi: 10.1002/bies.202400257
San Gil, Rebecca, Pascovici, Dana, Venturato, Juliana, Brown-Wright, Heledd, Mehta, Prachi, Madrid San Martin, Lidia, Wu, Jemma, Luan, Wei, Chui, Yi Kit, Bademosi, Adekunle T., Swaminathan, Shilpa, Naidoo, Serey, Berning, Britt A., Wright, Amanda L., Keating, Sean S., Curtis, Maurice A., Faull, Richard L. M., Lee, John D., Ngo, Shyuan T., Lee, Albert, Morsch, Marco, Chung, Roger S., Scotter, Emma, Lisowski, Leszek, Mirzaei, Mehdi and Walker, Adam K. (2024). A transient protein folding response targets aggregation in the early phase of TDP-43-mediated neurodegeneration. Nature Communications, 15 (1) 1508, 1508. doi: 10.1038/s41467-024-45646-9
Jacobs, Matisse T., San Gil, Rebecca and Walker, Adam K. (2023). UndERACting ion channels in neurodegeneration. Trends in Neurosciences, 47 (2), 87-89. doi: 10.1016/j.tins.2023.11.002
Luan, Wei, Wright, Amanda L., Brown-Wright, Heledd, Le, Sheng, San Gil, Rebecca, Madrid San Martin, Lidia, Ling, Karen, Jafar-Nejad, Paymaan, Rigo, Frank and Walker, Adam K. (2023). Early activation of cellular stress and death pathways caused by cytoplasmic TDP-43 in the rNLS8 mouse model of ALS and FTD. Molecular Psychiatry, 28 (6), 2445-2461. doi: 10.1038/s41380-023-02036-9
Keating, Sean S., Bademosi, Adekunle T., San Gil, Rebecca and Walker, Adam K. (2023). Aggregation-prone TDP-43 sequesters and drives pathological transitions of free nuclear TDP-43. Cellular and Molecular Life Sciences, 80 (4) 95, 1-23. doi: 10.1007/s00018-023-04739-2
Keating, Sean S., San Gil, Rebecca, Swanson, Molly E.V., Scotter, Emma L. and Walker, Adam K. (2022). TDP-43 pathology: from noxious assembly to therapeutic removal. Progress in Neurobiology, 211 102229, 102229. doi: 10.1016/j.pneurobio.2022.102229
Wright, Amanda L., Della Gatta, Paul A., Le, Sheng, Berning, Britt A., Mehta, Prachi, Jacobs, Kelly R., Gul, Hossai, San Gil, Rebecca, Hedl, Thomas J., Riddell, Winonah R., Watson, Owen, Keating, Sean S., Venturato, Juliana, Chung, Roger S., Atkin, Julie D., Lee, Albert, Shi, Bingyang, Blizzard, Catherine A., Morsch, Marco and Walker, Adam K. (2021). Riluzole does not ameliorate disease caused by cytoplasmic TDP‐43 in a mouse model of amyotrophic lateral sclerosis. European Journal of Neuroscience, 54 (6) ejn.15422, 6237-6255. doi: 10.1111/ejn.15422
San Gil, Rebecca, Clarke, Benjamin E., Ecroyd, Heath, Kalmar, Bernadett and Greensmith, Linda (2021). Regional differences in heat shock protein 25 expression in brain and spinal cord astrocytes of wild-type and SOD1 G93A mice. Cells, 10 (5) 1257, 1-18. doi: 10.3390/cells10051257
San Gil, Rebecca (2020). First person - Rebecca San Gil. Journal of Cell Science, 133 (15) jcs251918, 1-2. doi: 10.1242/jcs.251918
Gil, R. San, Cox, D., McAlary, L., Berg, T., Walker, A. K., Yerbury, J. J., Ooi, L. and Ecroyd, H. (2020). Neurodegenerative disease-associated protein aggregates are poor inducers of the heat shock response in neuronal cells. Journal of Cell Science, 133 (15), 1-15. doi: 10.1242/jcs.243709
Hedl, Thomas J., San Gil, Rebecca, Cheng, Flora, Rayner, Stephanie L., Davidson, Jennilee M., De Luca, Alana, Villalva, Maria D., Ecroyd, Heath, Walker, Adam K. and Lee, Albert (2019). Proteomics approaches for biomarker and drug target discovery in ALS and FTD. Frontiers in Neuroscience, 13 (JUN) 548, 548. doi: 10.3389/fnins.2019.00548
Clarke, Benjamin E., Gil, Rebecca San, Yip, Jing, Kalmar, Bernadett and Greensmith, Linda (2019). Regional differences in the inflammatory and heat shock response in glia: implications for ALS. Cell Stress and Chaperones, 24 (5), 857-870. doi: 10.1007/s12192-019-01005-y
Cox, Dezerae, Whiten, Daniel R., Brown, James W. P., Horrocks, Mathew H., San Gil, Rebecca, Dobson, Christopher M., Klenerman, David, van Oijen, Antoine M. and Ecroyd, Heath (2018). The small heat shock protein Hsp27 binds α-synuclein fibrils, preventing elongation and cytotoxicity. Journal of Biological Chemistry, 293 (12), 4486-4497. doi: 10.1074/jbc.m117.813865
San Gil, Rebecca, Ooi, Lezanne, Yerbury, Justin J. and Ecroyd, Heath (2017). The heat shock response in neurons and astroglia and its role in neurodegenerative diseases. Molecular Neurodegeneration, 12 (1) 65. doi: 10.1186/s13024-017-0208-6
San Gil, Rebecca, Berg, Tracey and Ecroyd, Heath (2017). Using bicistronic constructs to evaluate the chaperone activities of heat shock proteins in cells. Scientific Reports, 7 (1) 2387. doi: 10.1038/s41598-017-02459-9
Whiten, D. R., San Gil, R., McAlary, L., Yerbury, J. J., Ecroyd, H. and Wilson, M. R. (2016). Rapid flow cytometric measurement of protein inclusions and nuclear trafficking. Scientific Reports, 6 (1) 31138. doi: 10.1038/srep31138