Dr Kelly Walton
Senior Research Fellow
School of Biomedical Sciences, Faculty of Medicine

Featured projects | Duration |
---|---|
Ribosomal profiling with cellular specificity Genome Innovation Hub Collaborative Project (UQ infrastructure) |
2023 |
Publications
Journal Articles
Hagg, Adam, O'Shea, Eliza, Harrison, Craig A. and Walton, Kelly Louise (2023). Targeting activins and inhibins to treat reproductive disorders and cancer cachexia. Journal of Endocrinology, 258 (1). doi: 10.1530/joe-22-0290
Kappes, Emily C, Kattamuri, Chandramohan, Czepnik, Magdalena, Yarawsky, Alexander E, Brûlé, Emilie, Wang, Ying, Ongaro, Luisina, Herr, Andrew B, Walton, Kelly L, Bernard, Daniel J and Thompson, Thomas B (2023). Follistatin forms a stable complex with Inhibin A that does not interfere with Activin A antagonism. Endocrinology, 164 (3) bqad017. doi: 10.1210/endocr/bqad017
Wang, Yi Tian, Harrison, Craig A., Skinner, Elizabeth H., Haines, Kimberley J., Holdsworth, Clare, Lang, Jenna K., Hibbert, Elizabeth, Scott, David, Eynon, Nir, Tiruvoipati, Ravindranath, French, Craig J., Stepto, Nigel K., Bates, Samantha, Walton, Kelly L., Crozier, Tim M. and Haines, Terry P. (2022). Activin A level is associated with physical function in critically ill patients. Australian Critical Care, 36 (5), 702-707. doi: 10.1016/j.aucc.2022.10.019
Walton, Kelly L., Goney, Monica P., Peppas, Zoe, Stringer, Jessica M., Winship, Amy, Hutt, Karla, Goodchild, Georgia, Maskey, Shreya, Chan, Karen L., Brûlé, Emilie, Bernard, Daniel J., Stocker, William A. and Harrison, Craig A. (2022). Inhibin inactivation in female mice leads to elevated FSH levels, ovarian over-stimulation, and pregnancy loss. Endocrinology, 163 (4) bqac025. doi: 10.1210/endocr/bqac025
Houston, Brendan J, O’Connor, Anne E, Wang, Degang, Goodchild, Georgia, Merriner, D Jo, Luan, Haitong, Conrad, Don F, Nagirnaja, Liina, Aston, Kenneth I, Kliesch, Sabine, Wyrwoll, Margot J, Friedrich, Corinna, Tüttelmann, Frank, Harrison, Craig, O’Bryan, Moira K and Walton, Kelly (2022). Human INHBB gene variant (c.1079T>C:p.Met360Thr) alters testisgerm cell content, but does not impact fertility in mice. Endocrinology, 163 (3) bqab269. doi: 10.1210/endocr/bqab269
Brûlé, Emilie, Wang, Ying, Li, Yining, Lin, Yeu-Farn, Zhou, Xiang, Ongaro, Luisina, Alonso, Carlos A. I., Buddle, Evan R. S., Schneyer, Alan L., Byeon, Chang-Hyeock, Hinck, Cynthia S., Mendelev, Natalia, Russell, John P., Cowan, Mitra, Boehm, Ulrich, Ruf-Zamojski, Frederique, Zamojski, Michel, Andoniadou, Cynthia L., Sealfon, Stuart C., Harrison, Craig A., Walton, Kelly L., Hinck, Andrew P. and Bernard, Daniel J. (2021). TGFBR3L is an inhibin B co-receptor that regulates female fertility. Science Advances, 7 (51) eabl4391, eabl4391. doi: 10.1126/sciadv.abl4391
Hart, Kaitlin N., Stocker, William A., Nagykery, Nicholas G., Walton, Kelly L., Harrison, Craig A., Donahoe, Patricia K., Pépin, David and Thompson, Thomas B. (2021). Structure of AMH bound to AMHR2 provides insight into a unique signaling pair in the TGF-β family. Proceedings of the National Academy of Sciences of the United States of America, 118 (26) e2104809118. doi: 10.1073/pnas.2104809118
Hagg, Adam, Kharoud, Swati, Goodchild, Georgia, Goodman, Craig A., Chen, Justin L., Thomson, Rachel E., Qian, Hongwei, Gregorevic, Paul, Harrison, Craig A. and Walton, Kelly L. (2020). TMEPAI/PMEPA1 is a positive regulator of skeletal muscle mass. Frontiers in Physiology, 11 560225, 560225. doi: 10.3389/fphys.2020.560225
Jaillard, Sylvie, Bell, Katrina, Akloul, Linda, Walton, Kelly, McElreavy, Kenneth, Stocker, William A., Beaumont, Marion, Harrisson, Craig, Jääskeläinen, Tiina, Palvimo, Jorma J., Robevska, Gorjana, Launay, Erika, Satié, Anne-Pascale, Listyasari, Nurin, Bendavid, Claude, Sreenivasan, Rajini, Duros, Solène, van den Bergen, Jocelyn, Henry, Catherine, Domin-Bernhard, Mathilde, Cornevin, Laurence, Dejucq-Rainsford, Nathalie, Belaud-Rotureau, Marc-Antoine, Odent, Sylvie, Ayers, Katie L., Ravel, Célia, Tucker, Elena J. and Sinclair, Andrew H. (2020). New insights into the genetic basis of premature ovarian insufficiency: novel causative variants and candidate genes revealed by genomic sequencing. Maturitas, 141, 9-19. doi: 10.1016/j.maturitas.2020.06.004
Goney, Monica P., Wilce, Matthew C. J., Wilce, Jacqueline A., Stocker, William A., Goodchild, Georgia M., Chan, Karen L., Harrison, Craig A. and Walton, Kelly L. (2020). Engineering the ovarian hormones inhibin A and inhibin B to enhance synthesis and activity. Endocrinology, 161 (8), 1-12. doi: 10.1210/endocr/bqaa099
Stocker, William A., Walton, Kelly L., Richani, Dulama, Chan, Karen L., Beilby, Kiri H., Finger, Bethany J., Green, Mark P., Gilchrist, Robert B. and Harrison, Craig A. (2020). A variant of human growth differentiation factor-9 that improves oocyte developmental competence. Journal of Biological Chemistry, 295 (23), 7981-7991. doi: 10.1074/jbc.ra120.013050
Walton, Kelly L., Chen, Justin L., Arnold, Quinn, Kelly, Emily, La, Mylinh, Lu, Louis, Lovrecz, George, Hagg, Adam, Colgan, Timothy D., Qian, Hongwei, Gregorevic, Paul and Harrison, Craig A. (2019). Activin A–induced cachectic wasting is attenuated by systemic delivery of its cognate propeptide in male mice. Endocrinology, 160 (10), 2417-2426. doi: 10.1210/en.2019-00257
Riepsamen, Angelique H., Chan, Karen, Lien, Shelly, Sweeten, Prudence, Donoghoe, Mark W., Walker, Glenda, Fraison, Eloïse H. J., Stocker, William A., Walton, Kelly L., Harrison, Craig A., Ledger, William L., Robertson, David M. and Gilchrist, Robert B. (2019). Serum concentrations of oocyte-secreted factors BMP15 and GDF9 during IVF and in women with reproductive pathologies. Endocrinology, 160 (10), 2298-2313. doi: 10.1210/en.2019-00264
Bouty, Aurore, Walton, Kelly, Listyasari, Nurin Aisyiyah, Robevska, Gorjana, Van den Bergen, Jocelyn, Santosa, Ardy, Faradz, Sultana M H, Harrison, Craig, Ayers, Katie L and Sinclair, Andrew H (2019). Functional characterization of two new variants in the bone morphogenetic protein 7 prodomain in two pairs of monozygotic twins with hypospadias. Journal of the Endocrine Society, 3 (4), 814-824. doi: 10.1210/js.2018-00333
Richani, Dulama, Constance, Katherine, Lien, Shelly, Agapiou, David, Stocker, William A., Hedger, Mark P., Ledger, William L., Thompson, Jeremy G., Robertson, David M., Mottershead, David G., Walton, Kelly L., Harrison, Craig A. and Gilchrist, Robert B. (2019). Cumulin and FSH Cooperate to Regulate Inhibin B and Activin B Production by Human Granulosa-Lutein Cells In Vitro. Endocrinology, 160 (4), 853-862. doi: 10.1210/en.2018-01026
Walton, Kelly L. and Harrison, Craig A. (2018). Inhibin: To Betaglycan, or Not to Betaglycan. Endocrinology, 160 (2), 341-342. doi: 10.1210/en.2018-01049
Walker, Ryan G., McCoy, Jason C., Czepnik, Magdalena, Mills, Melanie J., Hagg, Adam, Walton, Kelly L., Cotton, Thomas R., Hyvönen, Marko, Lee, Richard T., Gregorevic, Paul, Harrison, Craig A. and Thompson, Thomas B. (2018). Molecular characterization of latent GDF8 reveals mechanisms of activation. Proceedings of the National Academy of Sciences of the United States of America, 115 (5), E866-E875. doi: 10.1073/pnas.1714622115
Chen, Justin L., Walton, Kelly L., Hagg, Adam, Colgan, Timothy D., Johnson, Katharine, Qian, Hongwei, Gregorevic, Paul and Harrison, Craig A. (2017). Specific targeting of TGF-β family ligands demonstrates distinct roles in the regulation of muscle mass in health and disease. Proceedings of the National Academy of Sciences of the United States of America, 114 (26), E5266-E5275. doi: 10.1073/pnas.1620013114
Wang, Yao, Chen, Qi, Zhao, Min, Walton, Kelly, Harrison, Craig and Nie, Guiying (2017). Multiple Soluble TGF-β Receptors in Addition to Soluble Endoglin Are Elevated in Preeclamptic Serum and They Synergistically Inhibit TGF-β Signaling. The Journal of Clinical Endocrinology & Metabolism, 102 (8), 3065-3074. doi: 10.1210/jc.2017-01150
Walker, Ryan G., Czepnik, Magdalena, Goebel, Erich J., McCoy, Jason C., Vujic, Ana, Cho, Miook, Oh, Juhyun, Aykul, Senem, Walton, Kelly L., Schang, Gauthier, Bernard, Daniel J., Hinck, Andrew P., Harrison, Craig A., Martinez-Hackert, Erik, Wagers, Amy J., Lee, Richard T. and Thompson, Thomas B. (2017). Structural basis for potency differences between GDF8 and GDF11. BMC Biology, 15 (1) 19. doi: 10.1186/s12915-017-0350-1
Patino, Liliana C., Walton, Kelly L., Mueller, Thomas D., Johnson, Katharine E., Stocker, William, Richani, Dulama, Agapiou, David, Gilchrist, Robert B., Laissue, Paul and Harrison, Craig A. (2017). BMP15 mutations associated with primary ovarian insufficiency reduce expression, activity, or synergy with GDF9. Journal of Clinical Endocrinology and Metabolism, 102 (3), 1009-1019. doi: 10.1210/jc.2016-3503
Coulson, Rhiannon, Liew, Seng H., Connelly, Angela A., Yee, Nicholas S., Deb, Siddhartha, Kumar, Beena, Vargas, Ana C., O'Toole, Sandra A., Parslow, Adam C., Poh, Ashleigh, Putoczki, Tracy, Morrow, Riley J., Alorro, Mariah, Lazarus, Kyren A., Yeap, Evie F.W., Walton, Kelly L., Harrison, Craig A., Hannan, Natalie J., George, Amee J., Clyne, Colin D., Ernst, Matthias, Allen, Andrew M. and Chand, Ashwini L. (2017). The angiotensin receptor blocker, Losartan, inhibits mammary tumor development and progression to invasive carcinoma. Oncotarget, 8 (12), 18640-18656. doi: 10.18632/oncotarget.15553
Chen, Justin L., Walton, Kelly L., Qian, Hongwei, Colgan, Timothy D., Hagg, Adam, Watt, Matthew J., Harrison, Craig A. and Gregorevic, Paul (2016). Differential effects of IL6 and activin A in the development of cancer-associated cachexia. Cancer Research, 76 (18), 5372-5382. doi: 10.1158/0008-5472.CAN-15-3152
Winbanks, Catherine E., Murphy, Kate T., Bernardo, Bianca C., Qian, Hongwei, Liu, Yingying, Sepulveda, Patricio V., Beyer, Claudia, Hagg, Adam, Thomson, Rachel E., Chen, Justin L., Walton, Kelly L., Loveland, Kate L., McMullen, Julie R., Rodgers, Buel D., Harrison, Craig A., Lynch, Gordon S. and Gregorevic, Paul (2016). Smad7 gene delivery prevents muscle wasting associated with cancer cachexia in mice. Science Translational Medicine, 8 (348). doi: 10.1126/scitranslmed.aac4976
Walton, Kelly L., Kelly, Emily K., Johnson, Katharine E., Robertson, David M., Stanton, Peter G. and Harrison, Craig A. (2016). A novel, more efficient approach to generate bioactive inhibins. Endocrinology, 157 (7), 2799-2809. doi: 10.1210/en.2015-1963
Chen, Justin L., Walton, Kelly L., Al-Musawi, Sara L., Kelly, Emily K., Qian, Hongwei, La, Mylinh, Lu, Louis, Lovrecz, George, Ziemann, Mark, Lazarus, Ross, El-Osta, Assam, Gregorevic, Paul and Harrison, Craig A. (2015). Development of novel activin-targeted therapeutics. Molecular Therapy, 23 (3), 434-444. doi: 10.1038/mt.2014.221
Tournier, Isabelle, Marlin, Régine, Walton, Kelly, Charbonnier, Françoise, Coutant, Sophie, Théry, Jean-Christophe, Charbonnier, Camille, Spurrell, Cailyn, Vezain, Myriam, Ippolito, Lorena, Bougeard, Gaëlle, Roman, Horace, Tinat, Julie, Sabourin, Jean-Christophe, Stoppa-Lyonnet, Dominique, Caron, Olivier, Bressac-de Paillerets, Brigitte, Vaur, Dominique, King, Mary-Claire, Harrison, Craig and Frebourg, Thierry (2014). Germline mutations of inhibins in early-onset ovarian epithelial tumors. Human Mutation, 35 (3), 294-297. doi: 10.1002/humu.22489
Nicholls, Peter K., Stanton, Peter G., Chen, Justin L., Olcorn, Justine S., Haverfield, Jenna T., Qian, Hongwei, Walton, Kelly L., Gregorevic, Paul and Harrison, Craig A. (2012). Activin signaling regulates sertoli cell differentiation and function. Endocrinology, 153 (12), 6065-6077. doi: 10.1210/en.2012-1821
Simpson, Courtney M., Stanton, Peter G., Walton, Kelly L., Chan, Karen L., Ritter, Lesley J., Gilchrist, Robert B. and Harrison, Craig A. (2012). Activation of latent human GDF9 by a single residue change (Gly391Arg) in the mature domain. Endocrinology, 153 (3), 1301-1310. doi: 10.1210/en.2011-1632
Makanji, Yogeshwar, Walton, Kelly L., Chan, Karen L., Gregorevic, Paul, Robertson, David M. and Harrison, Craig A. (2011). Generation of a specific activin antagonist by modification of the activin A propeptide. Endocrinology, 152 (10), 3758-3768. doi: 10.1210/en.2011-1052
Walton, Kelly L., Makanji, Yogeshwar, Chen, Justin, Wilce, Matthew C., Chan, Karen L., Robertson, David M. and Harrison, Craig A. (2010). Two distinct regions of latency-associated peptide coordinate stability of the latent transforming growth factor-β1 complex. Journal of Biological Chemistry, 285 (22), 17029-17037. doi: 10.1074/jbc.M110.110288
Walton, Kelly L., Makanji, Yogeshwar, Wilce, Matthew C., Chan, Karen L., Robertson, David M. and Harrison, Craig A. (2009). A common biosynthetic pathway governs the dimerization and secretion of inhibin and related transforming growth factor β(TGFβ) ligands. Journal of Biological Chemistry, 284 (14), 9311-9320. doi: 10.1074/jbc.M808763200
Makanji, Yogeshwar, Walton, Kelly L., Wilce, Matthew C., Chan, Karen L., Robertson, David M. and Harrison, Craig A. (2008). Suppression of inhibin A biological activity by alterations in the binding site for betaglycan. Journal of Biological Chemistry, 283 (24), 16743-16751. doi: 10.1074/jbc.M801045200