The Genome Innovation Hub continually develops a number of protocols and procedures while undertaking our collaborative projects. Below are a selection of detailed developments useful to researchers undertaking genomic-related advanced imaging in the laboratory.

Developments

Featured projects Duration
Developing new "spatial omics" capabilities
Genome Innovation Hub Collaborative Project (UQ infrastructure)
2021
Automated single cell quantitative in situ gene expression in cells and tissues (AutoMerFISH)
Genome Innovation Hub Collaborative Project (UQ infrastructure)
2019
Spatial genomics technologies to study cancer and genetic diseases in tissue contexts
Genome Innovation Hub Collaborative Project (UQ infrastructure)
2019

Publications

Spatial analysis of ligand-receptor interactions in skin cancer at genome-wide and single-cell resolution

M Tran, S Yoon, ST Min, S Andersen, K Devitt, PY Lam, B Purdue, A Raghubar, SJ Hanson, K Jones, S Walters, ZK Tuong, HP Soyer, I Frazer, Q Nguyen

bioRxiv 2020.09.10.290833

 

Spatially resolved transcriptome profiles of mammalian kidneys illustrate the molecular complexity of functional nephron segments, cell-to-cell interactions and genetic variants

Arti M. Raghubar, Duy T. Pham, Xiao Tan, Laura F. Grice, Joanna Crawford, Pui Yeng Lam, Stacey B. Andersen, Sohye Yoon, Monica S.Y. Ng, Siok Min Teoh, Samuel E. Holland,  Anne Stewart,  Leo Francis, Alexander N. Combes, Andrew J. Kassianos, Helen Healy, Quan Nguyen, Andrew J. Mallett

bioRxiv 2020.09.29.317917

 

stLearn: integrating spatial location, tissue morphology and gene expression to find cell types, cell-cell interactions and spatial trajectories within undissociated tissues

Duy Pham, Xiao Tan, Jun Xu, Laura F. Grice, Pui Yeng Lam, Arti Raghubar, Jana Vukovic, Marc J. Ruitenberg, Quan Nguyen

 bioRxiv 2020.05.31.125658;

 

SpaCell: integrating tissue morphology and spatial gene expression to predict disease cells

Xiao Tan, Andrew Su, Minh Tran, Quan Nguyen, SpaCell: integrating tissue morphology and spatial gene expression to predict disease cells

Bioinformatics, Volume 36, Issue 7, 1 April 2020, Pages 2293–2294,

  • Dr Hannah Leeson

    Postdoctoral Research Fellow
    Australian Institute for Bioengineering and Nanotechnology
  • A/Prof Andrew Mallett

    A/Prof Andrew Mallett

    Adjunct Senior Fellow
    Institute for Molecular Bioscience
    Associate Professor
    Royal Brisbane Clinical Unit, Faculty of Medicine
  • A/Prof Jessica Mar

    Associate Professor Jessica Mar

    ARC Future Fellow
    Australian Institute for Bioengineering and Nanotechnology (AIBN)
    Affiliate Research Fellow
    Institute for Molecular Bioscience (IMB)
  • Dr Shyuan Ngo

    Dr Shyuan Ngo

    Group Leader
    Australian Institute for Bioengineering and Nanotechnology
    Affiliate Senior Research Fellow
    Queensland Brain Institute
  • Dr Quan Nguyen

    Dr Quan Nguyen

    Senior Research Fellow - Group Leader
    Institute for Molecular Bioscience
  • Professor Ernst Wolvetang

    Professor Ernst Wolvetang

    Senior Group Leader
    Australian Institute for Bioengineering and Nanotechnology
  • Dr Sohye Yoon

    Dr Sohye Yoon

    Research Assistant
    Genome innovation Hub