Dr Nathan Palpant
Senior Research Fellow - GL
Institute for Molecular Bioscience
| Featured projects | Duration |
|---|---|
|
Precise genome editing Genome Innovation Hub Collaborative Project (UQ infrastructure) |
2019 |
|
Dual gRNA screen Genome Innovation Hub Collaborative Project (UQ infrastructure) |
2019 |
Book
Dilley, Stephen and Palpant, Nathan J. (2013). Human dignity in bioethics: From worldviews to the public square. New York, United States: Routledge. doi: 10.4324/9780203075005
Book Chapters
Zhu, Wei-Zhong, Filice, Dominic, Palpant, Nathan J. and Laflamme, Michael A. (2014). Methods for assessing the electromechanical integration of human pluripotent stem cell-derived cardiomyocyte grafts. Cardiac tissue engineering: methods and protocols. (pp. 229-247) edited by Radisci, Milica and Black III, Lauren D.. New York, NY United States: Springer New York. doi: 10.1007/978-1-4939-1047-2_20
Palpant, Nathan J. and Holland, Suzanne (2013). Human dignity and the debate over early human embryos. Human dignity in bioethics: from worldviews to the public square. (pp. 239-263) New York, NY, United States: Routledge. doi: 10.4324/9780203075005
Dilley, Stephen and Palpant, Nathan J. (2013). Human dignity in the throes?: An introduction to the volume. Human Dignity in Bioethics: From Worldviews to the Public Square. (pp. 3-18) New York, NY United States: Taylor and Francis. doi: 10.4324/9780203075005
Journal Articles
Redd, Meredith A., Scheuer, Sarah E., Saez, Natalie J., Yoshikawa, Yusuke, Chiu, Han Sheng, Gao, Ling, Hicks, Mark, Villanueva, Jeanette E., Joshi, Yashutosh, Chow, Chun Yuen, Cuellar-Partida, Gabriel, Peart, Jason N., See Hoe, Louise E., Chen, Xiaoli, Sun, Yuliangzi, Suen, Jacky Y., Hatch, Robert J., Rollo, Ben, Alzubaidi, Mubarak A.H., Maljevic, Snezana, Quaife-Ryan, Gregory A., Hudson, James E., Porrello, Enzo R., White, Melanie Y., Cordwell, Stuart J., Fraser, John F., Petrou, Steven, Reichelt, Melissa E., Thomas, Walter G. ... Palpant, Nathan J. (2021). Therapeutic inhibition of acid sensing ion channel 1a recovers heart function after ischemia-reperfusion injury. Circulation. doi: 10.1161/circulationaha.121.054360
Kojic, Marija, Gawda, Tomasz, Gaik, Monika, Begg, Alexander, Salerno-Kochan, Anna, Kurniawan, Nyoman D., Jones, Alun, Drożdżyk, Katarzyna, Kościelniak, Anna, Chramiec-Głąbik, Andrzej, Hediyeh-Zadeh, Soroor, Kasherman, Maria, Shim, Woo Jun, Sinniah, Enakshi, Genovesi, Laura A., Abrahamsen, Rannvá K., Fenger, Christina D., Madsen, Camilla G., Cohen, Julie S., Fatemi, Ali, Stark, Zornitza, Lunke, Sebastian, Lee, Joy, Hansen, Jonas K., Boxill, Martin F., Keren, Boris, Marey, Isabelle, Saenz, Margarita S., Brown, Kathleen ... Wainwright, Brandon J. (2021). Elp2 mutations perturb the epitranscriptome and lead to a complex neurodevelopmental phenotype. Nature Communications, 12 (1) 2678, 2678. doi: 10.1038/s41467-021-22888-5
Neavin, Drew, Nguyen, Quan, Daniszewski, Maciej S., Liang, Helena H., Chiu, Han Sheng, Wee, Yong Kiat, Senabouth, Anne, Lukowski, Samuel W., Crombie, Duncan E., Lidgerwood, Grace E., Hernández, Damián, Vickers, James C., Cook, Anthony L., Palpant, Nathan J., Pébay, Alice, Hewitt, Alex W. and Powell, Joseph E. (2021). Single cell eQTL analysis identifies cell type-specific genetic control of gene expression in fibroblasts and reprogrammed induced pluripotent stem cells. Genome Biology, 22 (1) 76, 1-19. doi: 10.1186/s13059-021-02293-3
Shim, Woo Jun, Sinniah, Enakshi, Xu, Jun, Vitrinel, Burcu, Alexanian, Michael, Andreoletti, Gaia, Shen, Sophie, Sun, Yuliangzi, Balderson, Brad, Boix, Carles, Peng, Guangdun, Jing, Naihe, Wang, Yuliang, Kellis, Manolis, Tam, Patrick P L, Smith, Aaron, Piper, Michael, Christiaen, Lionel, Nguyen, Quan, Bodén, Mikael and Palpant, Nathan J. (2020). Conserved epigenetic regulatory logic infers genes governing cell identity. Cell Systems, 11 (6), 625-639.e13. doi: 10.1016/j.cels.2020.11.001
Millar, Jonathan E., Bartnikowski, Nicole, Passmore, Margaret R., Obonyo, Nchafatso G, Malfertheiner, Maximillian V., von Bahr, Viktor, Redd, Meredith A., See Hoe, Louise, Ki, Katrina K., Pedersen, Sanne, Boyle, Andrew J., Baillie, J Kenneth, Shekar, Kiran, Palpant, Nathan, Suen, Jacky Y., Matthay, Michael A., McAuley, Daniel F., Fraser, John F. and Combining Extracorporeal Life Support and Cell Therapy in Critical Illness (CELTIC) investigators (2020). Combined mesenchymal stromal cell therapy and ECMO in ARDS: a controlled experimental study in sheep. American Journal of Respiratory and Critical Care Medicine, 202 (3) rccm.201911-2143OC, 383-392. doi: 10.1164/rccm.201911-2143oc
Xu, Jun, Falconer, Caitlin, Nguyen, Quan, Crawford, Joanna, McKinnon, Brett D., Mortlock, Sally, Senabouth, Anne, Andersen, Stacey, Chiu, Han Sheng, Jiang, Longda, Palpant, Nathan J., Yang, Jian, Mueller, Michael D., Hewitt, Alex W., Pébay, Alice, Montgomery, Grant W., Powell, Joseph E. and Coin, Lachlan J. M. (2019). Genotype-free demultiplexing of pooled single-cell RNA-seq. Genome Biology, 20 (1) 290, 290. doi: 10.1186/s13059-019-1852-7
Neidig, Lauren E., Weinberger, Florian, Palpant, Nathan J., Mignone, John, Martinson, Amy M., Sorensen, Daniel W., Bender, Ingrid, Nemoto, Natsumi, Reinecke, Hans, Pabon, Lil, Molkentin, Jeffery D., Murry, Charles E. and van Berlo, Jop H. (2018). Evidence for minimal cardiogenic potential of stem cell sntigen 1-positive cells in the adult mouse heart. Circulation, 138 (25), 2960-2962. doi: 10.1161/CIRCULATIONAHA.118.035273
Friedman, Clayton E., Nguyen, Quan, Lukowski, Samuel W., Helfer, Abbigail, Chiu, Han Sheng, Miklas, Jason, Levy, Shiri, Suo, Shengbao, Han, Jing-Dong Jackie, Osteil, Pierre, Peng, Guangdun, Jing, Naihe, Baillie, Greg J., Senabouth, Anne, Christ, Angelika N., Bruxner, Timothy J., Murry, Charles E., Wong, Emily S., Ding, Jun, Wang, Yuliang, Hudson, James, Ruohola-Baker, Hannele, Bar-Joseph, Ziv, Tam, Patrick P.L., Powell, Joseph E. and Palpant, Nathan J. (2018). Single-cell transcriptomic analysis of cardiac differentiation from human PSCs reveals HOPX-dependent cardiomyocyte maturation. Cell Stem Cell, 23 (4), 586-598. doi: 10.1016/j.stem.2018.09.009
Vagnozzi, Ronald J., Sargent, Michelle A., Lin, Suh-Chin J., Palpant, Nathan J., Murry, Charles E. and Molkentin, Jeffery D. (2018). Genetic lineage tracing of Sca-1 cells reveals endothelial but not myogenic contribution to the murine heart. Circulation, 138 (25), CIRCULATIONAHA.118.035210-2939. doi: 10.1161/CIRCULATIONAHA.118.035210
Nguyen, Quan H., Lukowski, Samuel W., Chiu, Han Sheng, Senabouth, Anne, Bruxner, Timothy J.C., Christ, Angelika N., Palpant, Nathan J. and Powell, Joseph E. (2018). Single-cell RNA-seq of human induced pluripotent stem cells reveals cellular heterogeneity and cell state transitions between subpopulations. Genome Research, 28 (7), 1053-1066. doi: 10.1101/gr.223925.117
Hofsteen, Peter, Robitaille, Aaron Mark, Strash, Nicholas, Palpant, Nathan, Moon, Randall T., Pabon, Lil and Murry, Charles E. (2018). ALPK2 promotes cardiogenesis in zebrafish and human pluripotent stem cells. iScience, 2, 88-100. doi: 10.1016/j.isci.2018.03.010
Ferreccio, Amy, Mathieu, Julie, Detraux, Damien, Logeshwaran, Somasundaram, Cavanaugh, Christopher, Sopher, Bryce, Fischer, Karin, Bello, Thomas, Hussein, Assis M., Levy, Shiri, Cook, Savannah, Sidhu, Sonia B, Artoni, Filippo, Palpant, Nathan J., Reinecke, Hans, Wang, Yuliang, Paddison, Patrick, Murry, Charles, Jayadev, Suman, Ware, Carol and Ruohola-Baker, Hannele (2018). Inducible CRISPR genome editing platform in naive human embryonic stem cells reveals JARID2 function in self-renewal. Cell Cycle, 17 (5), 1-15. doi: 10.1080/15384101.2018.1442621
Muttenthaler, Markus, Andersson, Asa, Vetter, Irina, Menon, Rohit, Busnelli, Marta, Ragnarsson, Lotten, Bergmayr, Christian, Arrowsmith, Sarah, Deuis, Jennifer R., Chiu, Han Sheng, Palpant, Nathan J., O'Brien, Margaret, Smith, Terry J., Wray, Susan, Neumann, Inga D., Gruber, Christian W., Lewis, Richard J. and Alewood, Paul F. (2017). Subtle modifications to oxytocin produce ligands that retain potency and improved selectivity across species. Science Signaling, 10 (508) eaan3398, 1-13. doi: 10.1126/scisignal.aan3398
Alexanian, Michael, Maric, Daniel, Jenkinson, Stephen P., Mina, Marco, Friedman, Clayton E., Ting, Ching-Chia, Micheletti, Rudi, Plaisance, Isabelle, Nemir, Mohamed, Maison, Damien, Kernen, Jasmin, Pezzuto, Iole, Villeneuve, Dominic, Burdet, Frederic, Ibberson, Mark, Leib, Stephen L., Palpant, Nathan J., Hernandez, Nouria, Ounzain, Samir and Pedrazzini, Thierry (2017). A transcribed enhancer dictates mesendoderm specification in pluripotency. Nature Communications, 8 (1) 1806, 1-19. doi: 10.1038/s41467-017-01804-w
Palpant, Nathan J., Wang, Yuliang, Hadland, Brandon, Zaunbrecher, Rebecca J., Redd, Meredith, Jones, Daniel, Pabon, Lil, Jain, Rajan, Epstein, Jonathan, Ruzzo, Walter L., Zheng, Ying, Bernstein, Irwin, Margolin, Adam and Murry, Charles E. (2017). Chromatin and transcriptional analysis of mesoderm progenitor cells identifies HOPX as a regulator of primitive hematopoiesis. Cell Reports, 20 (7), 1597-1608. doi: 10.1016/j.celrep.2017.07.067
Zamir, Lyad, Singh, Reena, Nathan, Elisha, Patrick, Ralph, Yifa, Oren, Yahalom-Ronen, Yfat, Arrafi, Alaa A., Schultheiss, Thomas M., Suo, Shengbao, Han, Jing-Dong Jackie, Peng, Guangdun, Jing, Naihe, Wang, Yuliang, Palpant, Nathan, Tam, Patrick P. L., Harveyz, Richard P. and Tzahor, Eldad (2017). Nkx2.5 marks angioblasts that contribute to hemogenic endothelium of the endocardium and dorsal aorta. ELife, 6 e20994. doi: 10.7554/eLife.20994
Palpant, Nathan J., Pabon, Lil, Friedman, Clayton E., Roberts, Meredith, Hadland, Brandon, Zaunbrecher, Rebecca J., Bernstein, Irwin, Zheng, Ying and Murry, Charles E. (2017). Generating high-purity cardiac and endothelial derivatives from patterned mesoderm using human pluripotent stem cells. Nature Protocols, 12 (1), 15-31. doi: 10.1038/nprot.2016.153
Szabo, Linda, Morey, Robert, Palpant, Nathan J., Wang, Peter L., Afari, Nastaran, Jiang, Chuan, Parast, Mana M., Murry, Charles E., Laurent, Louise C. and Salzman, Julia (2016). Erratum to: Statistically based splicing detection reveals neural enrichment and tissue-specific induction of circular RNA during human fetal development [Genome Biology, 16, (2016) (126)], DOI: 10.1186/s13059-015-0690-5. Genome Biology, 17 (1) 263. doi: 10.1186/s13059-016-1123-9
Nakano, Atsushi, Nakano, Haruko, Smith, Kelly A. and Palpant, Nathan J. (2016). The developmental origins and lineage contributions of endocardial endothelium. Biochimica et Biophysica Acta. Molecular Cell Research, 1863 (7), 1937-1947. doi: 10.1016/j.bbamcr.2016.01.022
Szabo, Linda, Morey, Robert, Palpant, Nathan J., Wang, Peter L., Afari, Nastaran, Jiang, Chuan, Parast, Mana M., Murry, Charles E., Laurent, Louise C. and Salzman, Julia (2015). Statistically based splicing detection reveals neural enrichment and tissue-specific induction of circular RNA during human fetal development. Genome Biology, 16 (1) 126. doi: 10.1186/s13059-015-0690-5
Palpant, Nathan J., Hofsteen, Peter, Pabon, Lil, Reinecke, Hans and Murry, Charles E. (2015). Cardiac development in zebrafish and human embryonic stem cells is inhibited by exposure to tobacco cigarettes and ecigarettes. PLoS ONE, 10 (5) 0126259, e0126259.1-e0126259. 19. doi: 10.1371/journal.pone.0126259
Palpant, Nathan J., Pabon, Lil, Roberts, Meredith, Hadland, Brandon, Jones, Daniel, Jones, Christina, Moon, Randall T., Ruzzo, Walter L., Bernstein, Irwin, Zheng, Ying and Murry, Charles E. (2015). Inhibition of β-catenin signaling respecifies anterior-like endothelium into beating human cardiomyocytes. Development (Cambridge), 142 (18), 3198-3209. doi: 10.1242/dev.117010
Palpant, Nathan J. and Murry, Charles E. (2014). Proliferation at the heart of preadolescence. Cell, 157 (4), 765-767. doi: 10.1016/j.cell.2014.04.025
Chong, James J. H., Yang, Xiulan, Don, Creighton W., Minami, Elina, Liu, Yen-Wen, Weyers, Jill J., Mahoney, William M., Van Biber, Benjamin, Cook, Savannah M., Palpant, Nathan J., Gantz, Jay A., Fugate, James A., Muskheli, Veronica, Gough, G. Michael, Vogel, Keith W., Astley, Cliff A., Hotchkiss, Charlotte E., Baldessari, Audrey, Pabon, Lil, Reinecke, Hans, Gill, Edward A., Nelson, Veronica, Kiem, Hans-Peter, Laflamme, Michael A. and Murry, Charles E. (2014). Human embryonic-stem-cell-derived cardiomyocytes regenerate non-human primate hearts. Nature, 510 (7504), 273-277. doi: 10.1038/nature13233
Palpant, Nathan J., Pabon, Lil, Rabinowitz, Jeremy S., Hadland, Brandon K., Stoick-Cooper, Cristi L., Paige, Sharon L., Bernstein, Irwin D., Moon, Randall T. and Murry, Charles E. (2013). Transmembrane protein 88: A Wnt regulatory protein that specifies cardiomyocyte development. Development (Cambridge), 140 (18), 3799-3808. doi: 10.1242/dev.094789
Murry, Charles E., Palpant, Nathan J. and MacLellan, W. Robb (2013). Cardiopoietry in motion. Journal of the American College of Cardiology, 61 (23), 2339-2340. doi: 10.1016/j.jacc.2013.03.028
Palpant, N. J. and Dudzinski, D. (2013). Zinc finger nucleases: looking toward translation. Gene Therapy, 20 (2), 121-127. doi: 10.1038/gt.2012.2
Gantz, Jan A., Palpant, Nathan J., Welikson, Robert E., Hauschka, Stephen D., Murry, Charles E. and Laflamme, Michael A. (2012). Targeted genomic integration of a selectable floxed dual fluorescence reporter in human embryonic stem cells. PLoS ONE, 7 (10) e46971, 1-9. doi: 10.1371/journal.pone.0046971
Shiba, Yuji, Fernandes, Sarah, Zhu, Wei-Zhong, Filice, Dominic, Muskheli, Veronica, Kim, Jonathan, Palpant, Nathan J., Gantz, Jay, Moyes, Kara W., Reinecke, Hans, Van Biber, Benjamin, Dardas, Todd, Mignone, John L., Izawa, Atsushi, Hanna, Ramy, Viswanathan, Mohan, Gold, Joseph D., Kotlikoff, Michael I., Sarvazyan, Narine, Kay, Matthew W., Murry, Charles E. and Laflamme, Michael A. (2012). Human ES-cell-derived cardiomyocytes electrically couple and suppress arrhythmias in injured hearts. Nature, 489 (7415), 322-325. doi: 10.1038/nature11317
Davis, J., Yasuda, S., Palpant, N.J., Martindale, J., Stevenson, T., Converso, K. and Metzger, J.M. (2012). Diastolic dysfunction and thin filament dysregulation resulting from excitation-contraction uncoupling in a mouse model of restrictive cardiomyopathy. Journal of Molecular and Cellular Cardiology, 53 (3), 446-457. doi: 10.1016/j.yjmcc.2012.05.018
Palpant, Nathan J. and Murry, Charles E. (2012). Regenerative medicine: reprogramming the injured heart. Nature, 485 (7400), 585-586. doi: 10.1038/485585a
Palpant, Nathan J., Houang, Evelyne M., Sham, Yuk Y. and Metzger, Joseph M. (2012). pH-responsive titratable inotropic performance of histidine-modified cardiac troponin i. Biophysical Journal, 102 (7), 1570-1579. doi: 10.1016/j.bpj.2012.01.024
Palpant, Nathan J., Bedada, Fikru B., Peacock, Brandon, Blazar, Bruce R., Metzger, Joseph M. and Tolar, Jakub (2011). Cardiac disease in mucopolysaccharidosis type I attributed to catecholaminergic and hemodynamic deficiencies. American Journal of Physiology - Heart and Circulatory Physiology, 300 (1), H356-H365. doi: 10.1152/ajpheart.00774.2010
Barnabei, Matthew S., Palpant, Nathan J. and Metzger, Joseph M. (2010). Influence of genetic background on ex vivo and in vivo cardiac function in several commonly used inbred mouse strains. Physiological Genomics, 42A (2), 103-113. doi: 10.1152/physiolgenomics.00071.2010
Palpant N.J., Houang E.M., Delport W., Hastings K.E.M., Onufriev A.V., Sham Y.Y. and Metzger J.M. (2010). Pathogenic peptide deviations support a model of adaptive evolution of chordate cardiac performance by troponin mutations. Physiological Genomics, 42 (2), 287-299. doi: 10.1152/physiolgenomics.00033.2010
Palpant, N.J. and Metzger, J.M. (2010). Aesthetic cardiology: adipose-derived stem cells for myocardial repair. Current Stem Cell Research and Therapy, 5 (2), 145-152. doi: 10.2174/157488810791268654
Palpant, Nathan J., Szatkowski, Michael L., Wang, Wang, Townsend, DeWayne, Bedada, Fikru B., Koch, Lauren G., Britton, Steven L. and Metzger, Joseph M. (2009). Artificial selection for whole animal low intrinsic aerobic capacity co-segregates with hypoxia-induced cardiac pump failure. PLoS One, 4 (7) e6117, e6117. doi: 10.1371/journal.pone.0006117
Palpant, Nathan J., D'Alecy, Louis G. and Metzger, Joseph M. (2009). Single histidine button in cardiac troponin I sustains heart performance in response to severe hypercapnic respiratory acidosis in vivo. FASEB Journal, 23 (5), 1529-1540. doi: 10.1096/fj.08-121996
Turner, Immanuel, Belema-Bedada, Fikru, Martindale, Joshua, Townsend, DeWayne, Wang, Wang, Palpant, Nathan, Yasuda, So-chiro, Barnabei, Matthew, Fomicheva, Ekaterina and Metzger, Joseph M. (2008). Molecular Cardiology in Translation: Gene, Cell and Chemical-Based Experimental Therapeutics for the Failing Heart. Journal of Cardiovascular Translational Research, 1 (4), 317-327. doi: 10.1007/s12265-008-9065-6
Palpant, Nathan J., Day, Sharlene M., Herron, Todd J., Converso, Kimber L. and Metzger, Joseph M. (2008). Single histidine-substituted cardiac troponin I confers protection from age-related systolic and diastolic dysfunction. Cardiovascular Research, 80 (2), 209-218. doi: 10.1093/cvr/cvn198
Palpant, Nathan J., Yasuda, So-ichiro, MacDougald, Ormond and Metzger, Joseph M. (2007). Non-canonical Wnt signaling enhances differentiation of Sca1+/c-kit+ adipose-derived murine stromal vascular cells into spontaneously beating cardiac myocytes. Journal of Molecular and Cellular Cardiology, 43 (3), 362-370. doi: 10.1016/j.yjmcc.2007.06.012
Conference Papers
Redd, M. A., Scheuer, S. E., Saez, N. J., Macdonald, P. S., Palpant, N. J. and King, G. F. (2020). A spider-venom peptide for preventing ischemic injuries of the heart: application to heart transplant and myocardial infarction. Venom Week, Gainesville, FL, United States, 4-7 March, 2020. Oxford, United Kingdom : Elsevier.
Nguyen, Quan H., Lukowski, Samuel W., Chiu, Han S., Friedman, Clayton E., Senabouth, Anne, Crowhurst, Liam, Bruxner, Timothy J. C., Christ, Angelika N., Hudson, James, Ding, Jun, Bar-Joseph, Ziv, Tam, Patrick P. L., Palpant, Nathan J. and Powell, Joseph E. (2018). Genetic networks modulating cell fate specification and contributing to cardiac disease risk in hiPSC-derived cardiomyocytes at single cell resolution. Human Genome Meeting 2018, Yokohama, Japan, 12-15 March 2018. London, United Kingdom: Henry Stewart Publications LLP. doi: 10.1186/s40246-018-0138-6
Palpant, Nathan, Wang, Yuliang, Hadland, Brandon, Zaunbrecher, Rebecca, Redd, Meredith, Pabon, Lil, Jain, Rajan, Epstein, Jonathan, Zheng, Ying, Bernstein, Irwin, Margolin, Adam and Murry, Charles (2017). Epigenetic and transcriptional analysis of mesoderm progenitor cells identifies HOPX as a novel regulator of hemogenic endothelium. 18th International Congress of Developmental Biology, Singapore, Singapore, 18 - 22 June 2017. E Park, Shannon, Clare Ireland: Elsevier Ireland. doi: 10.1016/j.mod.2017.04.263
Bhattacharjee, N., Palpant, N. J., Murry, C. E. and Folch, A. (2015). Elevated microjet gradient device for directing spatiotemporal differentiation of embryonic stem cells. MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2015, Gyeongju, South Korea, 25-29 October 2015. San Diego, CA United States: Chemical and Biological Microsystems Society.