Dr Brooke Gardiner

Zheng, Hou-Feng, Forgetta, Vincenzo, Hsu, Yi-Hsiang, Estrada, Karol, Rosello-Diez, Alberto, Leo, Paul J., Dahia, Chitra L., Park-Min, Kyung Hyun, Tobias, Jonathan H., Kooperberg, Charles, Kleinman, Aaron, Styrkarsdottir, Unnur, Liu, Ching-Ti, Uggla, Charlotta, Evans, Daniel S., Nielson, Carrie M., Walter, Klaudia, Pettersson-Kymmer, Ulrika, McCarthy, Shane, Eriksson, Joel, Kwan, Tony, Jhamai, Mila, Trajanoska, Katerina, Memari, Yasin, Min, Josine, Huang, Jie, Danecek, Petr, Wilmot, Beth, Li, Rui ... UK10K Consortium (2015). Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture. Nature, 526 (7571), 112-117. doi: 10.1038/nature14878

Costello, Mary-Ellen, Ciccia, Francesco, Willner, Dana, Warrington, Nicole, Robinson, Philip C., Gardiner, Brooke, Marshall, Mhairi, Kenna, Tony J., Triolo. Giovanni and Brown, Matthew A. (2015). Brief report: intestinal dysbiosis in ankylosing spondylitis. Arthritis and Rheumatology, 67 (3), 686-691. doi: 10.1002/art.38967

McInerney-Leo, Aideen, Sparrow, Duncan B., Harris, Jessica, Gardiner, Brooke, Marshall, Mhairi, O'Reilly, Victoria C., Shi, Hongjun, Brown, Matthew A., Leo, Paul, Zankl, Andreas, Dunwoodie, Sally L. and Duncan, Emma (2015). Compound heterozygous mutations in RIPPLY2 associated with vertebral segmentation defects. Human Molecular Genetics, 24 (5), 1234-1242. doi: 10.1093/hmg/ddu534

McInerney-Leo, Aideen, Harris, Jessica E., Leo, Paul, Marshall, Mhairi, Gardiner, Brooke, Kinning, Esther, Leong, Huey Yin, McKenzie, Fiona, Ong, PeiTee, Vodopiutz, Julia, Wicking, Carol A., Brown, Matthew A., Zanki, Andreas and Duncan, Emma (2015). Whole exome sequencing is an efficient, sensitive and specific method for determining the genetic cause of short-rib thoracic dystrophies. Clinical Genetics, 88 (6), 550-557. doi: 10.1111/cge.12550

McInerney-Leo, A. M., Duncan, E. L., Leo, P. J., Gardiner, B., Bradbury, L. A., Harris, J. E., Clark, G. R., Brown, M. A. and Zankl, A. (2014). COL1A1 C-propeptide cleavage site mutation causes high bone mass, bone fragility and jaw lesions: a new cause of gnathodiaphyseal dysplasia?. Clinical Genetics, 88 (1), 49-55. doi: 10.1111/cge.12440

McInerney-Leo, Aideen M., Marshall, Mhairi S., Gardiner, Brooke, Benn, Diana E., McFarlane, Janelle, Robinson, Bruce G., Brown, Matthew A., Leo, Paul J., Clifton-Bligh, Roderick J. and Duncan, Emma L. (2014). Whole exome sequencing is an efficient and sensitive method for detection of germline mutations in patients with phaeochromcytomas and paragangliomas. Clinical Endocrinology, 80 (1), 25-33. doi: 10.1111/cen.12331

McInerney-Leo, Aideen M., Marshall, Mhairi S., Gardiner, Brooke, Coucke, Paul J., Van Laer, Lut, Loeys, Bart L., Summers, Kim M., Symoens, Sofie, West, Jennifer A., West, Malcolm J., Wordsworth, B. Paul, Zankl, Andreas, Leo, Paul J., Brown, Matthew A. and Duncan, Emma L. (2013). Whole exome sequencing is an efficient, sensitive and specific method of mutation detection in osteogenesis imperfecta and Marfan syndrome. BoneKEy Reports, 2 (456), 1-9. doi: 10.1038/bonekey.2013.190

Schmidts, Miriam, Vodopiutz, Julia, Christou-Savina, Sonia, Cortés, Claudio R., McInerney-Leo, Aideen M., Emes, Richard D., Arts, Heleen H., Tüysüz, Beyhan, D'Silva, Jason, Leo, Paul J., Giles, Tom C., Oud, Machteld M., Harris, Jessica A., Koopmans, Marije, Marshall, Mhairi, Elçioglu, Nursel, Kuechler, Alma, Bockenhauer, Detlef, Moore, Anthony T., Wilson, Louise C., Janecke, Andreas R., Hurles, Matthew E., Emmet, Warren, Gardiner, Brooke, Streubel, Berthold, Dopita, Belinda, Zankl, Andreas, Kayserili, Hülya, Scambler, Peter J. ... Mitchison, Hannah M. (2013). Mutations in the gene encoding IFT dynein complex component WDR34 cause Jeune asphyxiating thoracic dystrophy. American Journal of Human Genetics, 93 (5), 932-944. doi: 10.1016/j.ajhg.2013.10.003

Halbritter, Jan, Bizet, Albane A., Schmidts, Miriam, Porath, Jonathan D., Braun, Daniela A., Gee, Heon Yung, McInerney-Leo, Aideen M., Krug, Pauline, Filhol, Emilie, Davis, Erica E., Airik, Rannar, Czarnecki, Peter G., Lehman, Anna M., Trnka, Peter, Nitschke, Patrick, Bole-Feysot, Christine, Schueler, Markus, Knebelmann, Bertrand, Burtey, Stephane, Szabo, Attila J., Tory, Kalman, Leo, Paul J., Gardiner, Brooke, McKenzie, Fiona A., Zankl, Andreas, Brown, Matthew A., Hartley, Jane L., Maher, Eamonn R., Li, Chunmei ... Hildebrandt, Friedhelm (2013). Defects in the IFT-B Component IFT172 Cause Jeune and Mainzer-Saldino Syndromes in Humans. American Journal of Human Genetics, 93 (5), 915-925. doi: 10.1016/j.ajhg.2013.09.012

McInerney-Leo, Aideen M., Schmidts, Miriam, Cortés, Claudio R., Leo, Paul J., Gener, Blanca, Courtney, Andrew D., Gardiner, Brooke, Harris, Jessica A., Lu, Yeping, Marshall, Mhairi, Scrambler, Peter J., Beales, Philip L., Brown, Matthew A., Zankl, Andreas, Mitchison, Hannah M., Duncan, Emma L., Wicking, Carol and UK10K Consortium (2013). Short-rib polydactyly and Jeune Syndromes are caused by mutations in WDR60. American Journal of Human Genetics, 93 (3), 515-523. doi: 10.1016/j.ajhg.2013.06.022

Sparrow, Duncan B., McInerney-Leo, Aideen, Gucev, Zoran S., Gardiner, Brooke, Marshall, Mhairi, Leo, Paul J., Chapman, Deborah L., Tasic, Velibor, Shishko, Abduhadi, Brown, Matthew A., Duncan, Emma L. and Dunwoodie, Sally L. (2013). Autosomal dominant spondylocostal dysostosis is caused by mutation in TBX6. Human Molecular Genetics, 22 (8), 1625-1631. doi: 10.1093/hmg/ddt012

Cloonan, Nicole, Wani, Shivangi, Xu, Qinying, Gu, Jian, Lea, Kristi, Heater, Sheila, Barbacioru, Catalin, Steptoe, Anita L., Martin, Hilary C., Nourbakhsh, Ehsan, Krishnan, Keerthana, Gardiner, Brooke, Wang, Xiaohui, Nones, Katia, Steen, Jason A., Matigan, Nicholas A., Wood, David L., Kassahn, Karin S., Waddell, Nic, Shepherd, Jill, Lee, Clarence, Ichikawa, Jeff, McKernan, Kevin, Bramlett, Kelli, Kuersten, Scott and Grimmond, Sean M. (2011). MicroRNAs and their isomiRs function cooperatively to target common biological pathways. Genome Biology: biology for the post-genomic era, 12 (12) R126, 1-20. doi: 10.1186/gb-2011-12-12-r126

Kolle, Gabriel, Shepherd, Jill L., Gardiner, Brooke, Kassahn, Karin S., Cloonan, Nicole, Wood, David L. A., Nourbakhsh, Ehsan, Taylor, Darrin F., Wani, Shivangi, Chy, Hun S., Zhou, Qi, McKernan, Kevin, Kuersten, Scott, Laslett, Andrew L. and Grimmond, Sean M. (2011). Deep-transcriptome and ribonome sequencing redefines the molecular networks of pluripotency and the extracellular space in human embryonic stem cells. Genome Research, 21 (12), 2014-2025. doi: 10.1101/gr.119321.110

Thiagarajan, Rathi D., Cloonan, Nicole, Gardiner, Brooke B., Mercer, Tim R., Kolle, Gabriel, Nourbaksh, Ehsan, Wani, Shivangi, Tang, Dave, Krishnan, Keerthana, Georgas, Kylie M., Rumballe, Bree A., Chiu, Han S., Steen, Jason A., Mattick, John S., Little, Melissa H. and Grimmond, Sean M. (2011). Refining transcriptional programs in kidney development by integration of deep RNA-sequencing and array-based spatial profiling. BMC Genomics, 12 (1) 441, 441-1-441-16. doi: 10.1186/1471-2164-12-441

Mercer, Tim R., Dinger, Marcel E., Bracken, Cameron P., Kolle, Gabriel, Szubert, Jan M., Korbie, Darren J., Askarian-Amiri, Marjan E., Gardiner, Brooke B., Goodall, Gregory J., Grimmond, Sean M. and Mattick, John S. (2010). Regulated post-transcriptional RNA cleavage diversifies the eukaryotic transcriptome. Genome Research, 20 (12), 1639-1650. doi: 10.1101/gr.112128.110

Tallack, Michael R., Whitington, Tom, Yuen, Wai Shan, Wainwright, Elanor N., Keys, Janelle R., Gardiner, Brooke B., Nourbakhsh, Ehsan, Cloonan, Nicole, Grimmond, Sean M., Bailey, Timothy L. and Perkins, Andrew C. (2010). A global role for KLF1 in erythropoiesis revealed by ChIP-seq in primary erythroid cells (vol 20, pg 1052, 2010). Genome Research, 20 (12), 1748-1748.

Suen, JY, Gardiner, B, Grimmond, S and Fairlie, DP (2010). Profiling gene expression induced by protease-activated receptor 2 (PAR2) activation in human kidney cells. PLoS One, 5 (11) e13809, e13809-1-e13809-14. doi: 10.1371/journal.pone.0013809

Tallack, Michael R., Whitington, Tom, Yuen, Wai Shan, Wainwright, Elanor N., Keys, Janelle R., Gardiner, Brooke B., Nourbakhsh, Ehsan, Cloonan, Nicole, Grimmond, Sean M., Bailey, Timothy L. and Perkins, Andrew C. (2010). A global role for KLF1 in erythropoiesis revealed by ChIP-seq in primary erythroid cells. Genome Research, 20 (8), 1052-1063. doi: 10.1101/gr.106575.110

Hudson, T. J., Anderson, W., Aretz, A., Barker, A. D., Grimmond, S. M., Pearson, J. V., Cloonan, N., Gardiner, B. A., Waddell, N. J., Wilson, P. J., Wainwright, B. J. and The International Cancer Genome Consortium (2010). International network of cancer genome projects. Nature, 464 (7291), 993-998. doi: 10.1038/nature08987

Dawson, Paul A., Huxley, S., Gardiner, B., Tran, T., McAuley, J. L., Grimmond, S. M., McGuckin, M. A. and Markovich, D. (2009). Reduced mucin sulfonation and impaired intestinal barrier function in the hyposulfataemic NaS1 null mouse. Gut, 58 (7), 910-919. doi: 10.1136/gut.2007.147595

Dawson, Paul Anthony, Gardiner, Brooke, Lee, Soohyun, Grimmond, Sean and Markovich, Daniel (2008). Kidney transcriptome reveals altered steroid homeostasis in NaS1 sulfate transporter null mice. Journal of Steroid Biochemistry And Molecular Biology, 112 (1-3), 55-62. doi: 10.1016/j.jsbmb.2008.08.003

Dinger, Marcel E., Amaral, Paulo P., Mercer, Tim R, Pang, Ken C., Bruce, Stephen J., Gardiner, Brooke B., Askarian-Amiri, Marjan E., Ru, Kelin, Solda, Giulia, Simons, Cas, Sunkin, Susan M., Crowe, Mark L., Grimmond, Sean M, Perkins, Andrew C. and Mattick, John S. (2008). Long Noncoding RNAs in mouse embryonic stem cell pluripotency and differentiation. Genome Research, 18 (9), 1433-1445. doi: 10.1101/gr.078378.108

Cloonan, Nicole, Forrest, Alistair R. R., Kolle, Gabriel, Gardiner, Brooke B. A., Faulkner, Geoffrey J., Brown, Mellissa K., Taylor, Darrin F ., Steptoe, Anita L., Wani, Shivangi, Bethel, Graeme, Robertson, Alan J., Perkins, Andrew C., Bruce, Stephen J., Clarence, C. Lee, Ranade, Swati S., Peckham, Heather E, Manning, Jonathan M, McKernan, Kevin J and Grimmond, Sean M (2008). Stem cell transcriptome profiling via massive-scale mRNA sequencing. Nature Methods, 5 (7), 613-619. doi: 10.1038/nmeth.1223

Smit, Darren J., Gardiner, Brooke B. and Sturm, Richard A. (2007). Osteonectin downregulates E-cadherin, induces Osteopontin and Focal adhesion kinase activity stimulating an invasive melanoma phenotype. International Journal of Cancer, 121 (12), 2653-2660. doi: 10.1002/ijc.23039

Bruce, Stephen J., Gardiner, Brooke B., Burke, Les J., Gongora, Milena, Grimmond, Sean M. and Perkins, Andrew C. (2007). Dynamic transcription programs during ES cell differentiation towards mesoderm in serum versus serum-free (BMP4) culture. BMC Genomics, 8 (1) 365, 1-26. doi: 10.1186/1471-2164-8-365

Laslett, Andrew L., Grimmond, Sean, Gardiner, Brooke, Stamp, Lincon, Lin, Adelia, Hawes, Susan M, Wormald, Sam, Nikolic-Paterson, David, Haylock, David and Pera, Martin F. (2007). Transcriptional analysis of early lineage commitment in human embryonic stem cells. BMC Developmental Biology, 7 (12) 12, 1-18. doi: 10.1186/1471-213X-7-12

Dawson, P. A., Gardiner, B., Grimmond, S. and Markovich, D. (2006). Transcriptional profile reveals altered hepatic lipid and cholesterol metabolism in hyposulfatemic NaS1 null mice. Physiological Genomics, 26 (2), 116-124. doi: 10.1152/physiolgenomics.00300.2005

Caruana, Georgina, Cullen-McEwen, Luise, Nelson, Amy L., Kostoulias, Xenia, Woods, Kyra, Gardiner, Brooke, Davis, Melissa J., Taylor, Darrin F., Teasdale, Rohan D., Grimmond, Sean M., Little, Melissa H. and Bertram, John F. (2006). Spatial gene expression in the T-stage mouse metanephros. Gene Expression Patterns, 6 (8), 807-825. doi: 10.1016/j.modgep.2006.02.001

Challen, G., Gardiner, B., Caruana, G., Kostoulias, X., Martinez, G., Crowe, M., Taylor, D. F., Bertram, J., Little, M. and Grimmond, S. M. (2005). Temporal and spatial transcriptional programs in murine kidney development. Physiological Genomics, 23 (2), 159-171. doi: 10.1152/physiolgenomics.00043.2005

Sturm, Richard A., Satyamoorthy, Kapaeth, Meier, Freidegund, Gardiner, Brooke B., Smit, Darren J., Vaidya, Bhavesh and Herlyn, Meenhard (2002). Osteonectin/SPARC induction by ectopic beta(3) integrin in human radial growth phase primary melanoma cells. Cancer Research, 62 (1), 226-232.

Qiu, L., Zhang, M., Sturm, R. A., Gardiner, B, Tonks, I, Kay, G and Parsons, P. G. (2000). Inhibition of melanin synthesis by cystamine in human melanoma cells. Journal of Investigative Dermatology, 114 (1), 21-27. doi: 10.1046/j.1523-1747.2000.00826.x

Maung, Kyaw Zeya, Gray, James X., Leo, Paul J., Bassal, Mahmoud, Brown, Anna L., Bray, Sarah C., Tiong, Ing Soo, Kok, Chung H., Deans, Andrew, Marshall, Mhairi, Gardiner, Brooke, Glazov, Evgeny A., Marlton, Paula, Gill, Devinder, Bik, Luen, Lewis, Ian D., D'Andrea, Richard J. and Gonda, Thomas J. (2014). Whole Exome Sequencing of Acute Myeloid Leukaemia Patients Identifies Somatic and Germline Mutations in Fanconi Anaemia Genes. 56th Annual Meeting of the American Society of Hematology, San Francisco, CA United States, 06-09 December 2014. Washington, DC United States: American Society of Hematology.

Duncan, Emma, McInerney-Leo, Aideen, Leo, Paul, Gardiner, Brooke, Marshall, Mhairi, Coucke, Paul, Loeys, Bart, West, Malcolm, West, Jennifer, Wordsworth, Paul, Zankl, Andreas, Brown, Matthew and van Laer, Lut (2013). Whole exome sequencing is a sensitive and cost-effective means of detecting mutations in patients with Marfan syndrome and osteogenesis imperfecta. Annual Meeting of the American Society for Bone and Mineral Research, Baltimore, MD, United States, 4-7 October 2013. Hoboken, NJ, United States: Wiley-Blackwell.

Costello, Mary-Ellen, Ciccia, Francesco, Gardiner, Brooke, Marshall, Mhairi, Willner, Dana, Kenna, Tony, Triolo, Giovanni and Brown, Matthew A. (2013). Evidence Of a Microbial Signature In The Intestinal Microbiome In Ankylosing Spondylitis.. 77th Annual Meeting of the American College of Rheumatology / 48th Annual Meeting of the Association of Rheumatology Health Professionals, San Diego CA, United States, 25-30 October 2013. Hoboken, NJ United States: John Wiley and Sons. doi: 10.1002/art.38216

Tallack, M, Whitington, T, Gardiner, B, Wainwright, E, Keys, J, Monet, M, Nourbakhsh, E, Cloonan, N, Grimmond, S, Bailey, T and Perkins, AC (2009). Klf1 regulatory networks in primary erythroid cells. 51st Annual Meeting of the American-Society-of-Hematology, New Orleans, LA, U.S.A., 5-8 December 2009. Washington, D.C., U. S. A.: American Society of Hematology.

Moritz, K., Dickinson, H., Grimmond, S., Gardiner, B., Boon, W-M, Bertram, J., Cullen-Mcewen, L., Cuffe, J., Slattery, C., Poronnik, P. and Caruana, G. (2008). Molecular mechanisms leading to a reduced nephron endowment following prenatal glucocorticoid exposure in the mouse. 44th Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology, Newcastle, Australia, 6-10 September 2008. Richmond, VIC, Australia: Wiley-Blackwell .

Gardiner, M. R., Gongora, M., Gardiner, B., Grimmond, S. and Perkins, A. C. (2007). Zebrafish klf4 plays a global role in primitive erythropoiesis. 15th Conference on Hemoglobin Switching, Oxford, England, 14-18 September 2006. La Jolla, CA, U.S.A.: Elsevier. doi: 10.1016/j.bcmd.2006.10.113

Perkins, A. C., Bruce, S., Dinger, M., Gardiner, B., Steptoe, A., Burke, L., Mattick, J. S. and Grimmond, S. M. (2006). Transcription factors, non-coding RNAs and ES cell differentiation in vitro and in vivo. 7th Transgenic Technology Meeting (TT2007), Brisbane, Australia, 12-14 February, 2007. Netherlands: Kluwer Academic. doi: 10.1007/s11248-006-9047-x

Dawson, P. A., Gardiner, B., Lee, S., Ku, and Markovich, D. (2005). Sulphate ions in mammalian physiology: lessons from sulphate transporter knock-out mice. AuPS/ASB Canberra 2005 Meeting, Canberra Rydges Lakeside Hotel, 27-30 September. Canberra: ANU.

Gardiner, Brooke Bridget Anne (2005). Molecular changes defining the transition from radial to vertical growth phase in melanoma. PhD Thesis, Institute for Molecular Bioscience, The University of Queensland. doi: 10.14264/107588

Dr Brooke Gardiner

Publications

Journal Articles

Conference Papers

Thesis

Areas of research