Dr Denuja Karunakaran
IMB Fellow
Institute for Molecular Bioscience
| Featured projects | Duration |
|---|---|
|
Combining novel scSLAM-seq technology with 10x Genomics Chromium to track microchanges in newly synthesised RNA Genome Innovation Hub Collaborative Project (UQ infrastructure) |
2020 |
Journal Articles
Wang, Yizhuo, Curson, James E.B., Ramnath, Divya, Das Gupta, Kaustav, Reid, Robert C., Karunakaran, Denuja, Fairlie, David P. and Sweet, Matthew J. (2024). Histone deacetylase 7 activates 6-phosphogluconate dehydrogenase via an enzyme-independent mechanism that involves the N-terminal protein-protein interaction domain. Biochemical Journal, 481 (21), 1569-1584. doi: 10.1042/bcj20240380
Wang, Yizhuo, Abrol, Rishika, Mak, Jeffrey Y. W., Das Gupta, Kaustav, Ramnath, Divya, Karunakaran, Denuja, Fairlie, David P. and Sweet, Matthew J. (2023). Histone deacetylase 7: a signalling hub controlling development, inflammation, metabolism and disease. The FEBS Journal, 290 (11), 2805-2832. doi: 10.1111/febs.16437
Das Gupta, Kaustav, Ramnath, Divya, von Pein, Jessica B., Curson, James E. B., Wang, Yizhuo, Abrol, Rishika, Kakkanat, Asha, Moradi, Shayli Varasteh, Gunther, Kimberley S., Murthy, Ambika M. V., Stocks, Claudia J., Kapetanovic, Ronan, Reid, Robert C., Iyer, Abishek, Ilka, Zoe C., Nauseef, William M., Plan, Manuel, Luo, Lin, Stow, Jennifer L., Schroder, Kate, Karunakaran, Denuja, Alexandrov, Kirill, Shakespear, Melanie R., Schembri, Mark A., Fairlie, David P. and Sweet, Matthew J. (2023). HDAC7 is an immunometabolic switch triaging danger signals for engagement of antimicrobial versus inflammatory responses in macrophages. Proceedings of the National Academy of Sciences, 120 (4) e2212813120, 1-12. doi: 10.1073/pnas.2212813120
Preston, Simon P., Stutz, Michael D., Allison, Cody C., Nachbur, Ueli, Gouil, Quentin, Tran, Bang Manh, Duvivier, Valerie, Arandjelovic, Philip, Cooney, James P., Mackiewicz, Liana, Meng, Yanxiang, Schaefer, Jan, Bader, Stefanie M., Peng, Hongke, Valaydon, Zina, Rajasekaran, Pravin, Jennison, Charlie, Lopaticki, Sash, Farrell, Ann, Ryan, Marno, Howell, Jess, Croagh, Catherine, Karunakaran, Denuja, Schuster-Klein, Carole, Murphy, James M., Fifis, Theodora, Christophi, Christopher, Vincan, Elizabeth, Blewitt, Marnie E. ... Pellegrini, Marc (2022). Epigenetic silencing of RIPK3 in hepatocytes prevents MLKL-mediated necroptosis from contributing to liver pathologies. Gastroenterology, 163 (6), 1643-1657.e14. doi: 10.1053/j.gastro.2022.08.040
Ramnath, Divya, Das Gupta, Kaustav, Wang, Yizhuo, Abrol, Rishika, Curson, James E. B., Lim, Junxian, Reid, Robert C., Mansell, Ashley, Blumenthal, Antje, Karunakaran, Denuja, Fairlie, David P. and Sweet, Matthew J. (2022). The histone deacetylase Hdac7 supports LPS‐inducible glycolysis and Il‐1β production in murine macrophages via distinct mechanisms. Journal of Leukocyte Biology, 111 (2), 327-336. doi: 10.1002/jlb.2mr1021-260r
Karunakaran, Denuja, Nguyen, My-Anh, Geoffrion, Michele, Vreeken, Dianne, Lister, Zachary, Cheng, Henry S., Otte, Nicola, Essebier, Patricia, Wyatt, Hailey, Kandiah, Joshua W., Jung, Richard, Alenghat, Francis J., Mompeon, Ana, Lee, Richard, Pan, Calvin, Gordon, Emma, Rasheed, Adil, Lusis, Aldons J., Liu, Peter, Matic, Ljubica Perisic, Hedin, Ulf, Fish, Jason E., Guo, Liang, Kolodgie, Frank, Virmani, Renu, van Gils, Janine M. and Rayner, Katey J. (2021). RIPK1 expression associates with inflammation in early atherosclerosis in humans and can be therapeutically silenced to reduce NF-κB activation and atherogenesis in mice. Circulation, 143 (2), 163-177. doi: 10.1161/CIRCULATIONAHA.118.038379
Karunakaran, Denuja, Turner, Adam W., Duchez, Anne-Claire, Soubeyrand, Sebastien, Rasheed, Adil, Smyth, David, Cook, David P., Nikpay, Majid, Kandiah, Joshua W., Pan, Calvin, Geoffrion, Michele, Lee, Richard, Boytard, Ludovic, Wyatt, Hailey, Nguyen, My-Anh, Lau, Paulina, Laakso, Markku, Ramkhelawon, Bhama, Alvarez, Marcus, Pietiläinen, Kirsi H., Pajukanta, Päivi, Vanderhyden, Barbara C., Liu, Peter, Berger, Scott B., Gough, Peter J., Bertin, John, Harper, Mary-Ellen, Lusis, Aldons J., McPherson, Ruth and Rayner, Katey J. (2020). Publisher Correction: RIPK1 gene variants associate with obesity in humans and can be therapeutically silenced to reduce obesity in mice. Nature Metabolism, 2 (10), 1181-1181. doi: 10.1038/s42255-020-00309-z
Karunakaran, Denuja, Turner, Adam W., Duchez, Anne-Claire, Soubeyrand, Sebastien, Rasheed, Adil, Smyth, David, Cook, David P., Nikpay, Majid, Kandiah, Joshua W., Pan, Calvin, Geoffrion, Michele, Lee, Richard, Boytard, Ludovic, Wyatt, Hailey, Nguyen, My-Anh, Lau, Paulina, Laakso, Markku, Ramkhelawon, Bhama, Alvarez, Marcus, Pietiläinen, Kirsi H., Pajukanta, Päivi, Vanderhyden, Barbara C., Liu, Peter, Berger, Scott B., Gough, Peter J., Bertin, John, Harper, Mary-Ellen, Lusis, Aldons J., McPherson, Ruth and Rayner, Katey J. (2020). RIPK1 gene variants associate with obesity in humans and can be therapeutically silenced to reduce obesity in mice. Nature Metabolism, 2 (10), 1113-1125. doi: 10.1038/s42255-020-00279-2
Perry-Nguyen, Dylan, Jung, Richard G., Labinaz, Alisha, Duchez, Anne-Claire, Dewidar, Omar, Simard, Trevor, Karunakaran, Denuja, Majeed, Kamran, Sarathy, Kiran, Li, Ruonan, Ramirez, Daniel, Di Santo, Pietro, Rochman, Rebecca, So, Derek, Foie, Nicolas and Hibbert, Benjamin (2020). Evaluation of an in vitro coronary stent thrombosis model for preclinical assessment. Platelets, 31 (2), 167-173. doi: 10.1080/09537104.2019.1595564
Karunakaran, Denuja (2018). Beyond cholesterol homeostasis: a novel role for PDZK1 in macrophage apoptosis and atherosclerosis. Atherosclerosis, 276, 168-170. doi: 10.1016/j.atherosclerosis.2018.07.012
Nguyen, My-Anh, Karunakaran, Denuja, Geoffrion, Michele, Cheng, Henry S., Tandoc, Kristofferson, Perisic Matic, Ljubica, Hedin, Ulf, Maegdefessel, Lars, Fish, Jason E. and Rayner, Katey J. (2018). Extracellular vesicles secreted by atherogenic macrophages transfer microRNA to inhibit cell migration. Arteriosclerosis Thrombosis and Vascular Biology, 38 (1), 49-63. doi: 10.1161/atvbaha.117.309795
Kavurma, Mary M., Rayner, Katey J. and Karunakaran, Denuja (2017). The walking dead: macrophage inflammation and death in atherosclerosis. Current opinion in lipidology, 28 (2), 91-98. doi: 10.1097/MOL.0000000000000394
Karunakaran, Denuja and Rayner, Katey J. (2016). Macrophage miRNAs in atherosclerosis. Biochimica Et Biophysica Acta-Molecular and Cell Biology of Lipids, 1861 (12), 2087-2093. doi: 10.1016/j.bbalip.2016.02.006
Karunakaran, Denuja, Geoffrion, Michele, Wei, Lihui, Gan, Wei, Richards, Laura, Shangari, Prakriti, DeKemp, Ella M., Beanlands, Rachelle A., Perisic, Ljubica, Maegdefessel, Lars, Hedin, Ulf, Sad, Subash, Guo, Liang, Kolodgie, Frank D., Virmani, Renu, Ruddy, Terrence and Rayner, Katey J. (2016). Targeting macrophage necroptosis for therapeutic and diagnostic interventions in atherosclerosis. Science Advances, 2 (7) e1600224, e1600224. doi: 10.1126/sciadv.1600224
Ouimet, Mireille, Koster, Stefan, Sakowski, Erik, Ramkhelawon, Bhama, van Solingen, Coen, Oldebeken, Scott, Karunakaran, Denuja, Portal-Celhay, Cynthia, Sheedy, Frederick J, Ray, Tathagat Dutta, Cecchini, Katharine, Zamore, Philip D, Rayner, Katey J, Marcel, Yves L, Philips, Jennifer A and Moore, Kathryn J (2016). Mycobacterium tuberculosis induces the miR-33 locus to reprogram autophagy and host lipid metabolism. Nature Immunology, 17 (6), 677-686. doi: 10.1038/ni.3434
Karunakaran, Denuja, Richards, Laura, Geoffrion, Michele, Barrette, Danyk, Gotfrit, Ryan J., Harper, Mary-Ellen and Rayner, Katey J. (2015). Therapeutic inhibition of miR-33 promotes fatty acid oxidation but does not ameliorate metabolic dysfunction in diet-induced obesity. Arteriosclerosis, Thrombosis, and Vascular Biology, 35 (12), 2536-2543. doi: 10.1161/atvbaha.115.306404
Karunakaran, Denuja, Thrush, A. Brianne, Nguyen, My-Anh, Richards, Laura, Geoffrion, Michele, Singaravelu, Ragunath, Ramphos, Eleni, Shangari, Prakriti, Ouimet, Mireille, Pezacki, John P., Moore, Kathryn J., Perisic, Ljubica, Maegdefessel, Lars, Hedin, Ulf, Harper, Mary-Ellen and Rayner, Katey J. (2015). Macrophage mitochondrial energy status regulates cholesterol efflux and is enhanced by anti-miR33 in atherosclerosis. Circulation Research, 117 (3), 266-278. doi: 10.1161/circresaha.117.305624
Kockx, Maaike, Karunakaran, Denuja, Traini, Mathew, Xue, Jing, Huang, Kuan Yen, Nawara, Diana, Gaus, Katharina, Jessup, Wendy, Robinson, Phillip J. and Kritharides, Leonard (2014). Pharmacological inhibition of dynamin II reduces constitutive protein secretion from primary human macrophages. PLoS ONE, 9 (10) e111186, e111186. doi: 10.1371/journal.pone.0111186
Nguyen, My-Anh, Karunakaran, Denuja and Rayner, Katey J (2014). Unlocking the door to new therapies in cardiovascular disease: microRNAs hold the key. Current Cardiology Reports, 16 (11) 539, 1-12. doi: 10.1007/s11886-014-0539-7
Karunakaran, Denuja and Rayner, Katey J. (2013). MicroRNAs in cardiovascular health: from order to disorder. Endocrinology, 154 (11), 4000-4009. doi: 10.1210/en.2013-1299
Rafatian, Naimeh, Karunakaran, Denuja, Rayner, Katey J., Leenen, Frans H. H., Milne, Ross W. and Whitman, Stewart C. (2013). Cathepsin G deficiency decreases complexity of atherosclerotic lesions in apolipoprotein E-deficient mice. American Journal of Physiology-Heart and Circulatory Physiology, 305 (8), H1141-H1148. doi: 10.1152/ajpheart.00618.2012
Karunakaran, Denuja, Kockx, Maaike, Owen, Dylan M., Burnett, John R., Jessup, Wendy and Kritharides, Leonard (2013). Protein kinase C controls vesicular transport and secretion of apolipoprotein E from primary human macrophages. Journal of Biological Chemistry, 288 (7), 5186-5197. doi: 10.1074/jbc.m112.428961
Magenau, Astrid, Benzing, Carola, Proschogo, Nicholas, Don, Anthony S., Hejazi, Leila, Karunakaran, Denuja, Jessup, Wendy and Gaus, Katharina (2011). Phagocytosis of IgG-coated polystyrene beads by macrophages induces and requires high membrane order. Traffic, 12 (12), 1730-1743. doi: 10.1111/j.1600-0854.2011.01272.x
Gardiner, Elizabeth E., Arthur, Jane F., Shen, Yang, Karunakaran, Denuja, Moore, Lynley A., Esch, Jan Schulte Am, Andrews, Robert K. and Berndt, Michael C. (2010). GPIb alpha-selective activation of platelets induces platelet signaling events comparable to GPVI activation events. Platelets, 21 (4), 244-252. doi: 10.3109/09537101003695339
Gardiner, E. E., Al-Tamimi, M., Mu, F. -T., Karunakaran, D., Thom, J. Y., Moroi, M., Andrews, R. K., Berndt, M. C. and Baker, R. I. (2008). Compromised ITAM-based platelet receptor function in a patient with immune thrombocytopenic purpura. Journal of Thrombosis and Haemostasis, 6 (7), 1175-1182. doi: 10.1111/j.1538-7836.2008.03016.x
Gardiner, Elizabeth E., Karunakaran, Denuja, Arthur, Jane F., Mu, Fi-Tjen, Powell, Maree S., Baker, Ross I., Hogarth, P. Mark, Kahn, Mark L., Andrews, Robert K. and Berndt, Michael C. (2008). Dual ITAM-mediated proteolytic pathways for irreversible inactivation of platelet receptors: de-ITAM-izing Fc gamma RIIa. Blood, 111 (1), 165-174. doi: 10.1182/blood-2007-04-086983
Andrews, Robert K., Karunakaran, Denuja, Gardiner, Elizabeth E. and Berndt, Michael C. (2007). Platelet receptor proteolysis - A mechanism for downregulating platelet reactivity. Arteriosclerosis Thrombosis and Vascular Biology, 27 (7), 1511-1520. doi: 10.1161/ATVBAHA.107.141390
Gardiner, E. E., Karunakaran, D., Shen, Y., Arthur, J. F., Andrews, R. K. and Berndt, M. C. (2007). Controlled shedding of platelet glycoprotein (GP)VI and GPIb-IX-V by ADAM family metalloproteinases. Journal of Thrombosis and Haemostasis, 5 (7), 1530-1537. doi: 10.1111/j.1538-7836.2007.02590.x
Conference Papers
Karunakaran, Denuja, Dwevidi, Girish and Rayner, Katey (2017). Macrophage Cholesterol Efflux and Atherosclerosis in Psoriasis: A role for microRNA‐33. Experimental Biology 2017 Meeting, Chicago, IL United States, 22-26 April 2017. Hoboken, NJ United States: John Wiley & Sons. doi: 10.1096/fasebj.31.1_supplement.947.7
Karunakaran, Denuja, Geoffrion, Michele, Lee, Richard, Wei, Lihui, Gan, Wei, Perisic, Ljubica, Maegdefessel, Lars, Hedin, Ulf, Sad, Subash, Guo, Liang, Kolodgie, Frank, Ruddy, Terrence, Virmani, Renu and Rayner, Katey (2017). Therapeutically inhibiting macrophage necroptosis reduces inflammation‐driven atherosclerosis and promotes plaque stability. Experimental Biology 2017 Meeting, Chicago, IL United States, 22-26 April 2017. Hoboken, NJ United States: John Wiley & Sons. doi: 10.1096/fasebj.31.1_supplement.327.2
My-Anh Nguyen,, Karunakaran, Denuja, Geoffrion, Michele, Cheng, Henry S., Matic, Ljubica P., Hedin, Ulf, Maegdefessel, Lars, Fish, Jason E. and Rayner, Katey J. (2017). Extracellular vesicles secreted by atherogenic macrophages transfer microrna to inhibit cell migration. American Heart Association's Arteriosclerosis, Thrombosis and Vascular Biology/Peripheral Vascular Disease Scientific Sessions, Minneapolis, MN, United States, 4-6 May, 2017. Philadelphia, PA, United States: Lippincott Williams & Wilkins.
Karunakaran, Denuja, Geoffrion, Michele, Wei, Lihui, Gan, Wei, Perisic, Ljubica, Maegdefessel, Lars, Hedin, Ulf, Sad, Subash, Virmani, Renu, Ruddy, Terrence and Rayner, Katey (2016). Targeting macrophage necroptosis for therapeutic and diagnostic interventions to treat atherosclerosis. Experimental Biology 2016 Meeting, San Diego, CA United States, 1-5 April 2016. Hoboken, NJ United States: John Wiley & Sons. doi: 10.1096/fasebj.30.1_supplement.444.6
Berndt, M. C., Karunakaran, D., Gardiner, E. E. and Andrews, R. K. (2007). Programmed autologous cleavage of platelet receptors. 21st Congress of the International-Society-on-Thrombosis-and-Haemostasis, Geneva Switzerland, Jul 06-12, 2007. HOBOKEN: WILEY. doi: 10.1111/j.1538-7836.2007.02484.x