Expertise
- Protein engineering
- Mass spectrometry
- Letivirus production
Researcher biography
Max has a research background in the fields of molecular and cellular biology with a focus on protein engineering. In 2012, he obtained his BSc from the University of Wollongong before moving to Victoria and completing a 1st Class honours degree at Monash University in 2014. He then moved to Queensland, successfully completing his PhD at Griffith Institute for Drug Discovery in 2018. During his PhD he secured the opportunity to embark on an overseas exchange at iHuman Institute, Shanghai Tech University in China, enhancing his molecular and cell biology expertise with a sound knowledge of Chemistry.
Since coming to GIH, Max's focus is to optimise highly efficient, scalable, precise genome editing. His knowledge of protein expression and purification has facilitated rapid progress in his aim of producing native Cas9 in addition to several recombinant Cas9 fusion proteins. One of these recombinant variants, Cas9/SNAP-tag fusion, necessitates covalently binding of engineered O6-benzylguanine (BG)-labelled repair templates to the SNAP-tagged recombinant Cas9 fusion protein, thus allowing Max to couple his protein expression proficiency with his sound chemical expertise.
| Featured projects | Duration |
|---|---|
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Automated single cell quantitative in situ gene expression in cells and tissues (AutoMerFISH) Genome Innovation Hub Collaborative Project (UQ infrastructure) |
2019 |
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Cas9 targeted enrichment for Nanopore sequencing Genome Innovation Hub Collaborative Project (UQ infrastructure) |
2023 |
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OmniCRISPR: a simultaneous and combinatorial approach to the generation of multiple precise genomic alterations Genome Innovation Hub Collaborative Project (UQ infrastructure) |
2020 |
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Simultaneous identification of RNA-chromatin interactions and transcriptomes in single cells Genome Innovation Hub Collaborative Project (UQ infrastructure) |
2020 |
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Dual gRNA screen Genome Innovation Hub Collaborative Project (UQ infrastructure) |
2019 |
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Optimised bioinformatics and validation pipeline for genome-wide CRISPR screening data Genome Innovation Hub Collaborative Project (UQ infrastructure) |
2021 |
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Genome-Phaser: protocol for fully phasing whole genome variants using haplotagging Genome Innovation Hub Collaborative Project (UQ infrastructure) |
2021 |
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Expanding the scope of multimodal single cell sequencing Genome Innovation Hub Collaborative Project (UQ infrastructure) |
2021 |
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HTS single cell CRISPR technology for experimental validation of population genetics and functional genomics discovery Genome Innovation Hub Collaborative Project (UQ infrastructure) |
2021 |
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Enabling population scale epigenomics for crop improvement Genome Innovation Hub Collaborative Project (UQ infrastructure) |
2021 |
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Using nanopore sequencing to test mRNA vaccine quality. Genome Innovation Hub Collaborative Project (UQ infrastructure) |
2022 |
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Division-based single-cell-sequencing Genome Innovation Hub Collaborative Project (UQ infrastructure) |
2022 |
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Multi-contact Pore-C Genome Innovation Hub Collaborative Project (UQ infrastructure) |
2022 |
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Identification and exploitation of genome landing pads for cattle. Genome Innovation Hub Collaborative Project (UQ infrastructure) |
2022 |
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Enrichment and analysis of siRNAs for topical RNAi applications. Genome Innovation Hub Collaborative Project (UQ infrastructure) |
2022 |
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Precise genome editing Genome Innovation Hub Collaborative Project (UQ infrastructure) |
2019 |
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Ribosomal profiling with cellular specificity Genome Innovation Hub Collaborative Project (UQ infrastructure) |
2023 |
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Using transposon-sequencing to probe whole cell protein-protein interactions Genome Innovation Hub Collaborative Project (UQ infrastructure) |
2019 |
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Proximity ligation sequencing of mixed bacterial communities Genome Innovation Hub Collaborative Project (UQ infrastructure) |
2023 |