Max's focus is to optimise highly efficient, scalable, precise genome editing. His knowledge of protein expression and purification has facilitated rapid progress in his aim of producing native Cas9 in addition to several recombinant Cas9 fusion proteins. One of these recombinant variants, Cas9/SNAP-tag fusion, necessitates covalently binding of engineered O6-benzylguanine (BG)-labelled repair templates to the SNAP-tagged recombinant Cas9 fusion protein, thus allowing Max to couple his protein expression proficiency with his sound chemical expertise.

Researcher biography

Max has a research background in the fields of molecular and cellular biology with a focus on protein engineering. In 2012, he obtained his BSc from the University of Wollongong before moving to Victoria and completing a 1st Class honours degree at Monash University in 2014. He then moved to Queensland, successfully completing his PhD at Griffith Institute for Drug Discovery in 2018. During his PhD he secured the opportunity to embark on an overseas exchange at iHuman Institute, Shanghai Tech University in China, enhancing his molecular and cell biology expertise with a sound knowledge of Chemistry.

Featured projects Duration
Precise genome editing
Genome Innovation Hub Collaborative Project (UQ infrastructure)
2019
Using transposon-sequencing to probe whole cell protein-protein interactions
Genome Innovation Hub Collaborative Project (UQ infrastructure)
2019
Automated single cell quantitative in situ gene expression in cells and tissues (AutoMerFISH)
Genome Innovation Hub Collaborative Project (UQ infrastructure)
2019
OmniCRISPR: a simultaneous and combinatorial approach to the generation of multiple precise genomic alterations
Genome Innovation Hub Collaborative Project (UQ infrastructure)
2020
Simultaneous identification of RNA-chromatin interactions and transcriptomes in single cells
Genome Innovation Hub Collaborative Project (UQ infrastructure)
2020
Dual gRNA screen
Genome Innovation Hub Collaborative Project (UQ infrastructure)
2019
Optimised bioinformatics and validation pipeline for genome-wide CRISPR screening data
Genome Innovation Hub Collaborative Project (UQ infrastructure)
2021
Genome-Phaser: protocol for fully phasing whole genome variants using haplotagging
Genome Innovation Hub Collaborative Project (UQ infrastructure)
2021
Expanding the scope of multimodal single cell sequencing
Genome Innovation Hub Collaborative Project (UQ infrastructure)
2021
HTS single cell CRISPR technology for experimental validation of population genetics and functional genomics discovery
Genome Innovation Hub Collaborative Project (UQ infrastructure)
2021
Enabling population scale epigenomics for crop improvement
Genome Innovation Hub Collaborative Project (UQ infrastructure)
2021