Genome Innovation Hub

Dr Brooke Purdue

Institute Manager
Diamantina Institute, Faculty of Medicine
+61 7 3343 6934
Dr Brooke Purdue

Brooke's experience in genetic manipulation and expression analysis spans nearly 20 years. Having worked in multiple research areas within both academia and industry, she brings both decades of management experience and a broad range of scientific knowledge. As the Operations Manager of GIH from 2019-2022, that experience enabled her to manage the diverse range of collaborative projects that GIH was involved in for the first 4 years of external project calls. In mid 2022, Brooke moved on from the GIH Operations Manager position to take up the role of Institute Manager at the UQ Diamantina Institute.

Featured projects Duration
Spatial genomics technologies to study cancer and genetic diseases in tissue contexts
Genome Innovation Hub Collaborative Project (UQ infrastructure)
 2019
Developing a scalable genome browser and repository for complex multi-omic datasets.
Genome Innovation Hub Collaborative Project (UQ infrastructure)
 2021

Publications

Journal Articles (8)
Conference Papers (2)

Journal Articles

Tran, M., Yoon, S., Teoh, M., Andersen, S., Lam, PY., Purdue, B. W., Raghubar, A., Hanson, S.J., Devitt, K., Jones, K., Walters, S., Monkman, J., Kulasinghe, A., Tuong, Z.K., Soyer, H.P., Frazer, I. H. and Nguyen, Q. (2022). A robust experimental and computational analysis framework at multiple resolutions, modalities and coverages. Frontiers in Immunology, 13. doi: 10.3389/fimmu.2022.911873
O'Brien, Shannon L., Johnstone, Elizabeth K.M., Devost, Dominic, Conroy, Jacinta, Reichelt, Melissa E., Purdue, Brooke W., Ayoub, Mohammed A., Kawai, Tatsuo, Inoue, Asuka, Eguchi, Satoru, Hébert, Terence E., Pfleger, Kevin D.G. and Thomas, Walter G. (2021). Corrigendum to “BRET-based assay to monitor EGFR transactivation by the AT1R reveals Gq/11 protein-independent activation and AT1R-EGFR complexes” [Biochem. Pharmacol. 158 (2108) 232–242] (Biochemical Pharmacology (2018) 158 (232–242), (S0006295218304386), (10.1016/j.bcp.2018.10.017)). Biochemical Pharmacology, 192 114756, 114756. doi: 10.1016/j.bcp.2021.114756
Wang, Zhen, Chan, Hsiu‐Wen, Gambarotta, Giovanna, Smith, Nicola J., Purdue, Brooke W., Pennisi, David J., Porrello, Enzo R., O'Brien, Shannon L., Reichelt, Melissa E., Thomas, Walter G. and Paravicini, Tamara M. (2021). Stimulation of the four isoforms of receptor tyrosine kinase ErbB4, but not ErbB1, confers cardiomyocyte hypertrophy. Journal of Cellular Physiology, 236 (12) jcp.30487, 8160-8170. doi: 10.1002/jcp.30487
O'Brien, Shannon L., Johnstone, Elizabeth K. M., Devost, Dominic, Conroy, Jacinta, Reichelt, Melissa E., Purdue, Brooke W., Ayoub, Mohammed A., Kawai, Tatsuo, Inoue, Asuka, Eguchi, Satoru, Hébert, Terence E., Pfleger, Kevin D.G. and Thomas, Walter G. (2018). BRET-based assay to monitor EGFR transactivation by the AT1R reveals Gq/11 protein-independent activation and AT1R-EGFR complexes. Biochemical Pharmacology, 158, 232-242. doi: 10.1016/j.bcp.2018.10.017
George, Amee J., Purdue, Brooke W., Gould, Cathryn M., Thomas, Daniel W., Handoko, Yanny, Qian, Hongwei, Quaife-Ryan, Gregory A., Morgan, Kylie A., Simpson, Kaylene J., Thomas, Walter G. and Hannan, Ross D. (2013). A functional siRNA screen identifies genes modulating angiotensin II-mediated EGFR transactivation. Journal of Cell Science, 126 (23), 5377-5390. doi: 10.1242/jcs.128280
Foster, Simon R., Porrello, Enzo R., Purdue, Brooke, Chan, Hsiu-Wen, Voigt, Anja, Frenzel, Sabine, Hannan, Ross D., Moritz, Karen M., Simmons, David G., Molenaar, Peter, Roura, Eugeni, Boehm, Ulrich, Meyerhof, Wolfgang and Thomas, Walter G. (2013). Expression, Regulation and Putative Nutrient-Sensing Function of Taste GPCRs in the Heart. PLoS ONE, 8 (5) e64579, e64579-1-e64579-10. doi: 10.1371/journal.pone.0064579
Pham, Vi, Wade, John D., Purdue, Brooke W. and Sexton, Patrick M. (2004). Spatial proximity between a photolabile residue in position 19 of salmon calcitonin and the amino terminus of the human calcitonin receptor. The Journal of Biological Chemistry, 279 (8), 6720-6729. doi: 10.1074/jbc.M307214200
Purdue, BW, Tilakaratne, N and Sexton, PM (2002). Molecular pharmacology of the calcitonin receptor. Receptors & Channels, 8 (3-4), 243-255. doi: 10.1080/10606820213681

Conference Papers

George, A. J., Purdue, B. W., Gould, K., Handoko, Y., Thomas, D. W., Morgan, K. A., Simpson, K. J., Thomas, W. G. and Hannan, R. D. (2012). A functional SiRNA screening approach to investigate the mechanism underlying GPCR-mediated EGFR Transactivation in Malignancy. 22nd Biennial Congress of the European Association for Cancer Research, Barcelona Spain, 07-10 July 2012. Oxford, United Kingdom: Pergamon. doi: 10.1016/S0959-8049(12)71277-7
Cully, T. R., Purdue, B. W., Thomas, W. G., Gregorevic, P. and Launikonis, B. S. (2012). Injection of rAAV-Orai1 in adult wt and dystrophic mice up-regulates store operated calcium entry. Collaborative Congress of the European-Society-of-Gene-and-Cell-Therapy/French-Society-of-Cell-and-Gene-Therapy, Versailles, France, 25-29 October 2012. New Rochelle, NY, United States: Mary Ann Liebert.

Areas of research

Genomics